|
T7477 |
Antazoline
|
|
Others
|
|
Antazoline has antihistamine and anticholinergic effects.It used to treat a variety of arrhythmias. |
|
T9353 |
OXOMEMAZINE
|
|
AChR
,
Histamine Receptor
|
|
Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. Oxomemazine is a selective antagonist of mycotoxins M1 receptors, showing high (Ki=84 nM, M1 receptors) and low ... |
|
T36949 |
Niaprazine
|
|
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2].
Niaprazine exhibits a low aff... |
|
T1278 |
Astemizole
|
Laridal,Histaminos,Paralergin |
Potassium Channel
,
Histamine Receptor
|
|
Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to re... |
|
T0147 |
Clemastine fumarate
|
HS-592 (fumarate),Meclastine fumarate,Meclastine (fumarate) |
Autophagy
,
Histamine Receptor
|
|
Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. |
|
T22501 |
2-Pyridylethylamine dihydrochloride
|
|
Histamine Receptor
|
|
2-Pyridylethylamine dihydrochloride is a Histamine H1 receptor agonist. |
|
T7085 |
Mebhydrolin
|
Mebhydroline |
Histamine Receptor
|
|
Mebhydrolin (Mebhydroline) is a specific histamine H1 receptor antagonist. |
|
T1469 |
Levocetirizine
|
Levocetirizine HCl |
Histamine Receptor
|
|
Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist. |
|
T0263 |
Chloropyramine hydrochloride
|
Nilfan,Alergosan,Halopyramine hydrochloride |
FAK
,
VEGFR
,
Histamine Receptor
|
|
Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist. |
|
T23297 |
(S)-(+)-Dimethindene maleate
|
|
AChR
,
Histamine Receptor
|
|
(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that inhibits muscarinic M1, M3, and M4 receptors. |
|
T13566 |
Bamirastine
|
TAK-427 |
Histamine Receptor
|
|
Bamirastine inhibits ligand binding to recombinant human histamine H1 receptor (rhH1R) with an IC50 value of 17.3 nM.Bamirastine has an inhibitory effect on allergic skin inflammation. |
|
T6426 |
Buclizine dihydrochloride
|
Longifene,Buclina,Buclizine HCl,UCB-4445 |
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine dihydrochloride binds to and ... |
|
T22842 |
HTMT dimaleate
|
Histamine Trifluoromethyl Toluidide Dimaleate |
Histamine Receptor
|
|
HTMT dimaleate (Histamine Trifluoromethyl Toluidide Dimaleate) is an H1 and H2 receptor agonist. |
|
T1097 |
Loratadine
|
SCH 29851,Loratidine |
Influenza Virus
,
Histamine Receptor
|
|
Loratadine (SCH 29851) is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central ne... |
|
T0092 |
Antazoline hydrochloride
|
Phenazocine HCl,Phenazoline hydrochloride,Antazoline HCl |
Histamine Receptor
|
|
Antazoline hydrochloride (Phenazoline hydrochloride), a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine. |
|
T22354 |
Levocetirizine Dihydrochloride
|
Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride |
Histamine Receptor
|
|
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydro... |
|
T83975 |
Fenclozine Maleate
|
S 1429 |
Histamine Receptor
|
|
Fenclozine Maleate (S 1429) is a potential histamine H1 receptor antagonist , which can be used to study fever, inflammation and pain. |
|
T7893 |
Bepotastine
|
Bepotastine free base |
Others
,
Histamine Receptor
|
|
Bepotastine (Bepotastine free base) free base is a histamine 1 (H1) receptor antagonis. |
|
T1115 |
Doxylamine succinate
|
Decapryn |
Histamine Receptor
|
|
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ... |
|
T1470L |
Fexofenadine hydrochloride
|
|
Histamine Receptor
|
|
Fexofenadine Hydrochloride is a carboxylated metabolic derivative of terfenadine and long-lasting selective histamine H1 receptor antagonist, with antihistaminic activity. |
|
T1822 |
Clemizole
|
|
HCV Protease
,
Histamine Receptor
|
|
Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication. |
|
T10100 |
QF0301B
|
|
5-HT Receptor
,
Adrenergic Receptor
|
|
|
|
T0246 |
Betahistine dihydrochloride
|
PT-9,Betahistine 2HCl |
Histamine Receptor
|
|
Betahistine dihydrochloride (Betahistine 2HCl) is a histamine analog and H1 receptor agonist that serves as a vasodilator. |
|
T0118 |
Mizolastine
|
SL 850324 |
Histamine Receptor
|
|
Mizolastine (SL 850324) (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis), hives. |
|
T10680 |
Carebastine
|
|
Histamine Receptor
|
|
Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor. |
|
T1822L |
Clemizole hydrochloride
|
|
HCV Protease
,
Histamine Receptor
|
|
Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) replication and NS4B's RNA binding. |
|
T4250 |
Bilastine
|
Bilaxten |
Histamine Receptor
|
|
Bilastine (Bilaxten) is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action. |
|
T10000 |
(±)-Tazifylline
|
|
Histamine Receptor
|
|
(±)-Tazifylline is a selective and long-acting antagonist of histamine H1 receptor. Tazifylline shows much lower affinity for H2 receptors, α- and β-adrenoceptors, 5-hydroxytryptamine and muscarinic receptor subtypes. |
|
T0053 |
Hydroxyzine Pamoate
|
Hydroxyzine embonate,Bobsule,Equipose |
Histamine Receptor
|
|
Hydroxyzine Pamoate (Bobsule) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does ca... |
|
T2533 |
Alcaftadine
|
R89674,Lastacaft |
Histamine Receptor
|
|
Alcaftadine (Lastacaft) is an H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis. |
|
T0246L |
Betahistine mesylate
|
Extovyl,Melopat,Meginalisk |
Histamine Receptor
|
|
Betahistine mesylate (Extovyl) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. |
|
T16759 |
Ritanserin
|
R 55667 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Ritanserin (R 55667) is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM), less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors. |
|
T0903 |
Cinnarizine
|
Stugeron,Cinarizine,Dimitronal,Stutgin |
Calcium Channel
,
Histamine Receptor
|
|
Cinnarizine (Stugeron) is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS. |
|
T2200 |
Hydroxyzine dihydrochloride
|
Hydroxyzine 2HCl |
Histamine Receptor
|
|
Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIR... |
|
T3979 |
Emedastine
|
LY188695,Emadine |
Histamine Receptor
|
|
Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its... |
|
T1266 |
Terfenadine
|
(±)-Terfenadine,MDL-991 |
Apoptosis
,
Potassium Channel
,
5-HT Receptor
,
Caspase
,
Na+/Ca2+ Exchanger
,
HER
,
AChR
,
Histamine Receptor
|
|
Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. |
|
T12489L |
Pimethixene maleate
|
Pimetixene maleate |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as we... |
|
T4195 |
Betahistine
|
PT 9 base,Vasomotal,Serc base |
Histamine Receptor
|
|
Betahistine (Vasomotal) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. Betahisti... |
|
T9084 |
Cetirizine Impurity B dihydrochloride
|
De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride |
Histamine Receptor
|
|
Cetirizine Impurity B dihydrochloride (De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride) is an impurity of Cetirizine dihydrochloride. Cetirizine is a second-generation antihistamine. Cetirizine is a specific, o... |
|
T19839 |
Oxatomide
|
Oxatomida |
P2X Receptor
,
Calcium Channel
,
5-HT Receptor
,
Histamine Receptor
|
|
Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be used to block ATP-induced currents in the human P2... |
|
T73447 |
NP10679
|
|
|
|
NP10679 is a selective, pH dependent GluN2B subunit -specific N-methyl-D-aspartate ( NMDA ) receptor inhibitor with high oral bioavailability and good brain penetration. NP10679 inhibits GluN2B with IC 50 s of 23 and 142... |
|
T40652 |
Meclizine
|
Meclozine |
Histamine Receptor
|
|
Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ... |
|
T26690 |
AVN-101
|
|
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
AVN-101 is a potent 5-HT7 receptor antagonist. |
|
T0162 |
Quetiapine
|
ICI204636,Quetiapin |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Histamine Receptor
|
|
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antago... |
|
T16541 |
Pirolate
|
CP-32387 |
Others
|
|
Pirolate is a receptor of histamine H1. |
|
T20951 |
Quifenadine
|
Phencarol,Fencarol,Fenatin |
|
|
Quifenadine, an H1-histamine receptor blocker, has antiarrhythmic properties. |
|
T70467 |
Alinastine
|
|
|
|
Alinastine is a noncompetitive histamine H1 receptor antagonist. |
|
T12703 |
ReN-1869 hydrochloride
|
NNC-05-1869 hydrochloride |
Histamine Receptor
|
|
ReN 1869 hydrochloride is a novel, selective antagonist of histamine H1 receptor. |
|
T27875 |
LY 150310
|
LY150310,LY-150310 |
|
|
LY 150310, a histamine H1-receptor antagonist, can alter prostanoid concentrations in vitro and in vivo. |
|
T70306 |
Loratadine N-oxide
|
|
|
|
Loratadine N-oxide is a metabolite of the histamine H1 receptor inverse agonist loratadine. |
